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The Standing Rules

How the series is written and drawn. Unbadged rules govern the case itself and hold on both surfaces. Anything that applies to only one carries a Comic only or Radio only tag.

The voice

Must hold

  • The voiceover never winks. The comedy is her commitment to the bit.
  • One tell per caption, and only what a PI has actually lived.
  • The overrun runs one clause past sense. Never three.
  • Affectionate, never contemptuous.

Why, and the finer points

  • The gap is the engine. The voiceover is always deadly serious; the stakes are always small and administrative. If a caption winks at the reader, it's wrong — the comedy is her total commitment to the bit, never a joke she's in on.
  • The tell — a true, hyper-specific detail from academic life that turns absurd the moment it's isolated. Never an invented absurdity: if a PI hasn't personally lived it, cut it. This is the recognition laugh, and it's what tells the reader we're one of them. Build it by escalating — general setting → domain detail → dry number → hyper-specific fragment tacked on after the sentence should have ended.

    Conference room → consent form → all eleven pages → including the optional saliva sample.

    Reviewer 2 is the exemplar — it closes The Quiet Participant. One tell per caption; never stack them.
  • Card and table vocabulary (The Stacked Deck's register, available to any case that wants it): the deal · the cut · a stacked deck · a full deck · the bottom of the deck · palming · a force · Lady Luck · a raw deal.

    Small blind / big blind is the one worth saving. A blind is money you commit before you see anything — which is allocation concealment — and blinds come in sizes, which is masking: the clinic sees assignments already made, the PI sees nothing at all. Two people at the same table, blind to different degrees. Best home is a script with room to explain who can see what, not a caption.
  • Repeat the slang on purpose. When a noir word has already been used in an earlier case, reusing it is a feature — the reader is learning the dialect alongside us, and the second and third appearances are where a word stops being decoration and becomes the narrator's actual vocabulary. Sings (the canary in The Quiet Participant, the fourth card in The Stacked Deck) is the model. This applies to genre slang only: repeating a tell, a metaphor or a plot turn is still a tic, because those get their power from being specific and used once.
  • Phrases beat nouns. "The no-cost extension" is a tell. "We spent four days on the acronym and about eleven minutes on the aims" is a better one, because it carries a scene. Bank nouns, but write phrases.
  • The strongest tells have a number in them. Ninety-one percent of fifty-nine. Eleven grants at five percent each. All eleven pages. The specificity is the joke — a vague version of any of these is just an observation.
  • A tell is not a title. A tell needs to be true and specific. A title also needs a second, genre-compatible meaning — which is why Adverse Events works and No-Cost Extension doesn't.
  • Test a tell on someone inside the field but outside the specialty. If it needs explaining, it's out — no matter how true it is. "Lost to follow-up" is a perfect description of this series and was cut for exactly this reason.
  • The bank. Nouns to build phrases from:

    Reviewer 2 · the no-cost extension · a biosketch last updated in 2019 · a data sharing plan written in ninety minutes · revise-and-resubmit · an IRB amendment for a typo · buying a laptop in September because the fiscal year ends · the $25 gift cards and the tax paperwork they generate · scored just outside the payline · a shared drive folder called FINAL_v3_USE_THIS · the co-investigator on eleven grants at five percent each · certifying effort percentages nobody has ever tracked · "in preparation" on a CV for three years · an email from your chair with the subject line "Quick question" · a REDCap project somebody built in 2019 and left · the recruitment flyer with the tear-off tabs

    Phrases already spent, so don't respend them: the optional saliva sample · four days on the acronym and eleven minutes on the aims · the answer you give, the one about contributing to the evidence base · ninety-one percent of fifty-nine · the report lists who reported · who counts the rows? · you people rotate · a monitor visit that took a year off my life · a limitations section nobody will ever read · the machine on four
  • The literal question. Somebody takes an institutional phrase at face value, out loud, in earnest, and it collapses. This is the series' most reliable joke and the one to hunt for in every scene — not every scene will yield one, but every scene should be looked at.

    "How can you drop out before you've been dropped in?" Connie, on a woman who was never enrolled. "The drawer that locks, or the drawer that's got a lock on it?" "Then why does it keep telling me my call is important to them?" "That's not a category. That's a shrug." Same instrument every time.

    What makes it work: the speaker is being literal on purpose, not clever. She is not making a joke, she is pointing out that the words do not survive being meant. It is a question far more often than it is a statement, because a question hands the absurdity to the listener instead of announcing it.

    What kills it: a simile (the parrot, the raccoon — those are a different and rarer move), a double negative, or any construction the audience can admire. It is nine words or fewer almost every time. If it needs a setup clause, it isn't this.

    Where to look: the vocabulary the work already uses. Drop out. No-show. Protocol deviation. Lost to follow-up. Informed consent. Limitations. Adverse event. Intent to treat. Every one of them is a phrase nobody hears anymore, which means every one of them can be heard.
  • The double register — one word that is literally correct in both worlds at once, so the noir sense and the research sense are both true and neither is a figure of speech. "It's going to read like one in the paper." Connie means the publication. A 1940s detective means the newspaper. Nobody is making a comparison; the word is simply doing two jobs.

    Not the same as the noir metaphor, which is everywhere already and is a different, cheaper move: the report had an alibi, gave the unit the third degree, sixty informants wearing wires. Those apply a detective word to a research object and ask the listener to enjoy the stretch. The double register asks nothing. It is invisible until you notice it, and then it is the best line in the scene.

    It has to survive the no-winking rule. The character is not punning and does not know she is funny. She means the research sense flatly and in earnest; the second meaning is the listener's to find. The moment a line is constructed so the audience can admire the construction, it's an ordinary pun and it's out.

    The architecture is already built on this and the dialogue has barely used it. PI (principal investigator / private investigator) is the frosted door. Trial is every study in the series. Case is every title. Adverse Events is the show. All concept-level. The line above is close to the only one that does it inside actual speech, which is where the room is.

    Unspent, and true in both senses: the record (on the record / the study record) · witness (a witness / witnessed consent) · intake (booking at a precinct / study intake) · screening (vetting somebody / the screening visit) · follow-up (following somebody / the follow-up visit) · tail (tailing a suspect / the tail of a distribution) · exposure (getting exposed / exposure in epidemiology) · control (control of a situation / the control group) · blind (a blind alley / a blinded trial) · custody (the evidence locker / chain of custody) · prior (a prior conviction / a prior) · the books (cooking them / the study books) · recruit · drop · washout.
  • The overrun — the metaphor that runs one clause past where it should have stopped. One clause, not three. Plausible, then a step too far, then stop. This is the delivery laugh, and its failure mode is length: cut the tail before it turns into a list. A reader fills in the blank better than a caption box can.

    I stared at it the way a raccoon stares at a motion-sensor porch light.
  • Tell and overrun are different tools. A weak tell is one the reader hasn't lived. A bad overrun is one that runs three clauses instead of one. Diagnose them separately — most flat lines are one or the other, rarely both.
  • Slang is the costume; the research detail is the load-bearing wall. When a line has to choose between period patter and domain specificity, keep the domain.
  • Affectionate, never contemptuous. It recognizes a shared experience; it never implies the reader is doing their job badly. That decides whether she forwards it to her PI.
  • Comic only Panel 6 loosens — the radio-serial sign-off. Everywhere else the voice is clipped and committed. In the button it relaxes and half-addresses the audience: contractions, "I guess," colloquial grammar. The only panel where the register softens, which is what makes it feel like an ending.

The two surfaces

Must hold

  • A comic page never inherits the drama’s shape — it finds its own tension.
  • Nothing in an episode is ever solved by software.
  • A case card carries only what both surfaces share.
  • Participant 31, every time, and nobody ever remarks on it.

Why, and the finer points

  • Radio only The radio era is paper-primary and never dated. Not "pre-computer" — push back far enough to remove the computers and you lose the vocabulary the comedy runs on. IRBs are 1974; the CONSORT flow diagram Connie fills in during The Invisible Line is 1996. The setting that works is the late nineties, never named: CONSORT and IRBs exist, answering machines are ordinary, and a computer is furniture you walk to rather than something that hands you an answer.

    Practical test: a computer may be the crime scene, never a convenience. Where the machine is the case — the thing a number was typed into, the status that was accurate and useless — it belongs on stage, and The Perfect Delivery's revelation needs a paper card held against a screen, because the transposition happened between them. What it may not be is an oracle you ask for facts that paper could have given you. Otherwise reach for drawers, envelopes, card indexes and files, which all make sound where a database query doesn't. No smartphones, and no jokes that date the decade in either direction. The comic is present day and has screens; the radio has paper. That contrast is the series, not an inconsistency.
  • A beat sheet is the radio version. The comic is a different shape. Not the same story with one panel swapped — in the present day the product names the cause, and an investigation can't survive being handed its answer. So a comic page never inherits the drama's four suspects; it finds its own tension. Three strategies so far, all proven: flashback, where the disaster happened before the platform existed (The Quiet Participant); near miss, where the page is present tense and the horror is what she was about to do, with nothing actually lost (The Invisible Line); and half saved, where the damage is already running and part of it is gone for good by the time anyone notices (The Perfect Delivery — six weeks lost, six weeks left). Pick one per page and never run the same one twice in a row.
  • A case card summarizes neither surface — only what both share. The strip is for a present-day buyer and discreetly shows a real feature doing its job. The episode is set in no particular year, is never solved by software, and earns its authority by not being about us — the education is the point and the argument for the platform is left for the listener to make. So a card written from the strip will be an advertisement and a card written from the episode will describe an instrument we sell. Neither is the case. The index entry gets the invariant: the trouble, the mechanism, and what it cost somebody. If a sentence on a card could be falsified by reading one of the two artifacts, it belongs on that artifact and not here.
  • Comic = now. Radio = then. The strips are present-day, where the platform exists. The radio dramas are set in Tracy's DRIFT era, before she had any of it. Same continuity, and the strip's flashback row is literally the show's back catalog.
  • The comic resolves with the product; the radio drama never does. A strip is marketing and may show the alert firing. An episode is a service to the field, and nothing in it may be solved by software — the case closes because she changed.
  • Radio only Both must have a beginning, a middle, and an end. A drama that stops so a guest can finish it isn't a story. The guest widens the case from one study to the field; they never complete it.
  • The strip names the lore; the drama unpacks it. A comic panel has room for one clause — "it's been two years since DRIFT" — and it reads as texture. The radio version has room for the whole joke: "The DRIFT trial. Daily Routines for Improved Follow-Through. We spent four days on the acronym and about eleven minutes on the aims." Every piece of lore gets used twice, at two compressions.
  • Studies get acronyms, never surnames. Trials are named by tortured backronym — the letters first, the words reverse-engineered — and everyone knows it and nobody says so. That's a tell in itself, and the acronyms accumulate across the series as a running joke the audience gets better at. Surnames and place names belong to cohorts and registries, not to somebody's first R21.
  • Participant 31, every time. Whatever the study, whatever the case, the person at the center of it is number thirty-one — and nobody in the world ever remarks on it. The moment a character says "it's always thirty-one" it stops being a running gag and becomes a bit. It's a joke that only exists for someone reading all eight.

    Why that number: in a sixty-person study, 31 is the exact middle of the roster — which is precisely where The Invisible Line says things go to be forgotten. Early numbers get attention, late ones get chased, and the middle is where a person becomes a row. It's also 13 backwards, for anyone who wants it.

    On screen it reads 031; spoken, it's thirty-one.
  • Spend tells deliberately. A tell used in a strip and again in its episode reads as a rhyme across media. The same tell in two different cases reads as a repeat. Track them.
  • Radio only The sponsor gets one line, near the very end, in the announcer's voice — and the guest is never asked what software they use. The show's authority comes from not being about us. Only the sign-off gag comes after it, deliberately: the joke is the reward for sitting through the credits and the ad, so it has to be the last thing anybody hears.
  • Radio only The announcer's opening and closing are fixed copy. Only the case title, the cameo credit (where there is one) and the rotating sign-off clause change between episodes.

    Opening: Welcome to Adverse Events. Transcribed stories from the case files of Dr. Tracy Grant, who writes the protocol, and Connie Chase, who makes it all happen. · The story you are about to hear is fiction. Any resemblance to your last study is purely coincidental and entirely predictable. · The Case of the ———.

    Closing: This has been The Case of the ———. Then, over the outro music, the cameo credit if the episode has one, the sponsor line, and last of all And even though [CLAUSE] whenever they hear us say it: this is Adverse Events. No host-and-guest banter — the sign-off is announcer copy only.

    Three things not to undo. The disclaimer declares fiction rather than asserting truth — Dragnet could claim truth because it dramatized real case files; ours are composites, and every draft that claimed truth needed an escape hatch. There is no comma before "and entirely predictable"; the run-on is the timing, and a pause telegraphs the joke. And the epithet splits the two leads on who writes the protocol versus who makes it happen — never on who runs the study or who does the science, both of which coordinators would rightly hear as saying the work is somebody else's. Owning the protocol is uncontroversially the PI's; everything after that belongs to both of them.
  • Radio only The sign-off gag, and how to write more of it. Modeled on Car Talk's "…whenever they hear us say it: this is NPR." The engine is a self-deprecating concession followed by a neutral institutional ID, and it has three requirements. The tag must concede nothing — an earlier draft ended "it is now in peer review," which is a claim, so every clause had to be an obstacle to peer review and most weren't. "Whenever they hear us" is the hinge: without it the line is a plain non-sequitur rather than a joke about this show. And the clause is always a rejection of the program by someone qualified to judge it, never a general grievance about research — the point is that everyone competent has condemned it and it announces itself anyway. Adverse events being real trial vocabulary means the tag also reads as a verdict on what you just heard.

    Every clause is present tense, because "whenever they hear us say it" governs it. A past perfect ("has determined," "has ruled") fights the hinge and reads as a one-time event rather than a standing verdict.

    The bank: Reviewer 2 recommends rejection without review · the IRB classifies this as greater than minimal risk · the data safety monitoring board recommends we stop · the participants would like it noted that they did not consent to any of this · the grants office rules this an unallowable expense · the biostatistician points out that our sample size is one · the journal desk-rejects it in under ninety minutes · the university would prefer we clarify that these views are our own · the reproducibility working group cannot replicate it · the program officer asks which specific aim this addresses · the institutional repository declines to assign it a DOI · our own communications office will not promote it · the compliance office requests a copy for the file · the ethics board asks whether listeners were debriefed afterward.

    The announcer speaks in the present day even though the drama does not. He already reads a sponsor line for a company that exists now, so REDCap, two-factor and language models are all fair game in his mouth — and still forbidden inside the scenes, where the late-nineties rule holds.

    Borrow from old-time radio, and credit it in the sign-off. This series is a pastiche of a genre, and the difference between a fan and a scavenger is whether you say where you got it. When an episode takes a bit from a real program, the announcer names it after the cameo credit and before the sponsor line, in one sentence, with the years: "With thanks to Burns and Allen, whose radio and TV show ran from 1929 to 1958." The years are not decoration. The audience likes learning something, and dates are the part that says we actually know the material.

    Only when there is a genuine borrow, or the line stops being a credit and becomes furniture, which is the same failure as crediting a cameo that doesn't exist. Episode one stays clean — it predates the convention and it is the sample episode, so it carries nothing that needs explaining.

    Borrow forms and running gags, never a signature line played straight. A lifted catchphrase either sails past the listener or reads as theft; a borrowed shape works on its own and rewards whoever recognizes it.

    The exception is a bit the whole episode is built on and credits by name. When a case is the homage rather than a scene that winks at one, the sign-off credit converts a lift into a tribute, and at that point the audience is owed the actual line. The Secret Handshake takes Costello's "I don't even know what I'm talking about" at Connie's breaking point, with every setup line around it built from the show's own names, so the famous words are the only thing borrowed. At most one such line per episode, never in an episode that isn't paying the credit, and never as the button.

    Claimed so far, so nobody spends them twice: Burns and Allen's sign-off, spent in The Big Set-Up. Abbott and Costello's Who's on First, spent in The Secret Handshake. Jack Benny's "I'm thinking it over" for a PI weighing software against paying her coordinator, which needs Connie to catch her at it so the cheapness stays affectionate. Fibber McGee and Molly's hall closet, for a records room nobody dares open, which only works if the episode is willing to spend the avalanche. And Yours Truly, Johnny Dollar, the man with the action-packed expense account, whose episodes were narrated as itemized expense reports — that one is not a borrow but a whole spine, and belongs to a case of its own rather than to a scene.

    The sign-off's own shape is Car Talk's and is not credited, because it is the house style rather than a borrowed bit: the closing clause and the "whenever they hear us" hinge come from there. It is also a nineties program, contemporary with the drama's setting rather than an inheritance from the genre. Worth revisiting if the credit convention ever starts to feel selective.

The cast & the ethics

Must hold

  • She solves it. The software is the break in the case, never the hero.
  • Never dramatize a failure of the product.
  • The participant is a person with a life, never a data point.
  • Every strip reads cold. No strip may depend on another.

Why, and the finer points

  • Names are puns that read as names first. Tracy Grant, Connie Chase, and the statistician Randy Miser — which at conversational speed is randomizer, a joke that only exists out loud and so has to be read at pace, never leaned on. Banked: Fisher for a later methodologist (R.A. Fisher invented randomized design — an allusion rather than a pun, so it wants a different character), and Randy's first live introduction, saved for whenever he's more than a voicemail: "The name's Miser. Randy Miser. But my friends call me Lucky."
  • Connie says "Tracy" to her face and "Dr. Grant" in narration. Formal about her, familiar to her — she's a partner at the agency, not staff, and a coordinator who calls her "Doctor" across a desk reads as hierarchy the series doesn't have. The nameplates carry the title contrast; the dialogue shouldn't repeat it.
  • Two leads, assigned by whose case it is. Tracy takes protocol, analysis, and rigor; Connie takes recruitment, delivery, and adherence. Never force the wrong lead onto a case — it's the fastest way to make a strip read false.
  • She solves it. The software is the break in the case, never the hero. It's the informant who calls at the right hour, not the detective.
  • Never dramatize a failure of the product. The catastrophe always belongs to the old way, in the past, on a named study that predates the platform. The present-day case is always caught early.
  • The participant is a person with a life, never a data point. Every resolution lands on a human outcome, not a metric.
  • Procedural, not serial. Every strip is self-contained and readable cold — Dragnet, not a soap opera. The throughline is the character: same heroine, same office, same voice. Readers hit these in whatever order the site gives them, so no strip may assume another has been read.
  • Running references are fine; dependencies are not. The DRIFT trial can recur as her one unsolved case, the way every detective has one. But if a first-time reader landing on any other strip loses anything by not knowing it, the reference is doing too much work — cut it back to flavor.

The page Comic only

Must hold

  • Six panels, or nine when the page needs the room.
  • The tonal break lands on a row break; the last row is the lit one.
  • Climax second-to-last, button last.
  • Never end on a capability claim.

Why, and the finer points

The look Comic only

Must hold

  • Black, white and brand purple. Nothing else.
  • No color anywhere until the product appears.
  • No real UI inside a panel. No exceptions.
  • Neither lead is ever drawn whole. Fragments, backs, hands, and objects.

Why, and the finer points

Voice direction Radio only

Must hold

  • No accent work. Cast for cadence.
  • A cue names a sound source, or removes one already heard. Never a fact.
  • Incidental phone voices are never cast — and never run a person through the trombone.
  • One cameo-shaped hole per episode, from episode two on: a self-contained line, never an exchange.
  • Credit the cameo in the outro — and only when there is one.
  • Tracy holds the floor — twice an episode, and never during the solve.
  • One breeze per episode, in the two-hander. Irrelevant, never explained, never the thing that solves it.

Why, and the finer points

The cases themselves live in the Casebook. Who Tracy and Connie are lives in The Agency and Its Leads. Drawing a single page is the artist brief.